The Use of Viruses to Treat Cancer - 578 Words

Everyday science is advancing and researchers are working hard to examine and investigate all the different possible ways to develop new viruses to cure cancer. A research paper published recently suggests that a genetically engineered poxvirus called JX-594 shows the greatest clinical potential for a couple of reasons. It spreads and replicates fast, does not mix into host DNA, easy to manipulate genetically, very immunogenic, and remarkably safe in both animal models and initial human clinical trials [19]. Furthermore, research was conducted recently to study the combination of a VV with irinotecan (CPT-11) for cancer treatment by endogenous carboxylesterase (CE) enzymes. Approximately 5% of CPT-11 is converted to more active chemotherapeutic SN-38. The study concluded that both CPT-11 and SN-38 did not interfere with VV spread or replication. Furthermore, the study showed that the combination of CE-virus and CPT-11 resulted in the death of more K-562 cancer cells in vitro in comparison to its non-CE counterpart and CPT-11 [20]. Another example is Talimogene Iaherparepvec (OncoVEX GM-CSF), which is developed by Bio Vex, which later was purchased by Amgen for $ 1 billion in 2011 [21]. The virus is based on herpes simplex (HSV-1) and in March 2013, the virus has successfully completed a phase three trial for advanced melanoma [22]. It is expected to be the first oncolytic agent to be approved in the west. Also, it was examined in a phase one trial for pancreatic cancer andShow MoreRelatedWhat Are Oncolytic Viruses?1225 Words   |  5 PagesWhat are Oncolytic Viruses? Oncolytic viruses are viruses that are either genetically manufactured or naturally made, that can kill cancer cells without affecting normal cells. The virus rapidly multiplies until the cancerous cell explodes. This releases the virus, tumor specific agents, and GM-CSF. This causes the immune system to recognize cancerous cells and fight them with the help of the virus. Who/When Was it Developed? The uses of viruses to treat cancer have been talked about since theRead MoreIdentify And Describe Three Groups Of Low G + C Gram Positive Bacteria1579 Words   |  7 Pagesdifficult to treat viral infections? Provide an example. It is difficult to treat viral infections because in viral replication the virus uses the cellular structures and pathways of the host to multiply. So, any strategy for the treatment of viral diseases that involves disrupting the viral replication may disrupt normal cellular processes on the host as well. We are also limited by the number of effective antiviral drugs on the market. The drugs that are available against viruses can be toxicRead MoreEssay On Cancer-Fighting Viruses1432 Words   |  6 PagesIn recent years, many types of research have been developed regarding cancer-fighting viruses. The possibility of creating an effective therapy for cancer using this kind of treatment is been explored and, so far the results are promising. Many Asian countries have already approved viro-therapy to treat some types of cancer and here, in the US, the FDA has approved in October 2015, the first oncolytic virus therapy, talimogene laherparepvec (T-VEC, or Imlygic ®) for the treatmen t of metastatic melanomaRead MoreEssay about Cancer1518 Words   |  7 PagesCancer   Ã‚  Ã‚  Ã‚  Ã‚  Right now, cancer is one of the most feared diseases in the world. In the early 1990s almost 6 million new cancer cases developed and more than 4 million deaths from cancers occurred. Also more than one-fifth of all deaths were caused by cancer and it has been predicted, by the American Cancer Society, that about 33% of Americans will eventually develop this disease. This is a huge disease that is killing people all over the world.   Ã‚  Ã‚  Ã‚  Ã‚  The field of cancer study is called OncologyRead MoreViruses And Its Effects On Humans1404 Words   |  6 PagesThough viruses may seem as though it only has the potential to cause harm, recent studies have surfaced to change its bad reputation. Common known viruses such as Ebola, rabies, influenza, HIV and more are known to show harmful reactions to humans, sometimes even possible to cause death. Because of the way they work, viruses such as the human immunodeficiency virus has been looked into in terms of reprogramming, ending in a result that could possibly be an option to treat another catastrophic epidemicRead MoreGene Therapy And Its Effects1619 Words   |  7 Pagesadvanced; there have been remarkable strides in its methods and an increase in the range of targetable diseases. Gene therapy is the modification of the genetic material within a cell for therapeutic purposes. It is used to treat or prevent diseases, inherited disorders, some cancers and viral infections by inserting a gene into a patient’s cell, through a viral vector as a delivery system, instead of using traditional medicine or surgery. Genes are responsible for making proteins, which in turn haveRead MoreAn Introduction Of An Oncolytic Virus ( Ov )1703 Words   |  7 Pagesoncolytic virus (OV) is a virus that preferentially infects and kills cancer cells. OVs posses the ability to selectively infect and replicate in cancer and associated endothelial cells and kill these cells in cancerous tissues while leaving normal tissues unharmed [1]. As the infected cancer cells are destroyed by lysis, they release new infectious virus particles to help destroy other cancer cells or the remaining tumor. The viruses achieve this by a number of mechanisms, including direct lysis, apoptosisRead M oreDisadvantages Of Adeno-Associated Viruses1403 Words   |  6 Pages However, adeno-associated viruses still have several drawbacks, firstly, regarding their integration into the host cell’s genome. The majority of AAV DNA remains episomal and does not integrate(21). This means the effect of the genes on cells is transient, and eventually, the transgenic DNA will be removed. This removal is slower than in adenoviruses due to reduced immunogenicity. A study looking at the treatment of haemophilia B in dogs found that AAV treatment could replace levels of factor IXRead MoreThe Detection And Treatment Of Cancer1554 Words   |  7 PagesHow is a greater understanding of genetics fuelling a change in our diagnosis and treatment of cancer? It is estimated by Cancer Research UK that one in two people in the UK will get cancer at some point in their lives . This startling statistic shows an inept global failure to bring about control of one of most prevalent and fatal known diseases. But the growth in cancer incidence is not confined to the UK; in 2012 14.1 million new people were diagnosed worldwide, with forty percent of these newRead MoreGenetic Engineering And Its Effects On Cancer Essay1818 Words   |  8 PagesIntroduction Cancer, one of the most feared and deadliest diseases that affects millions of people around the world, may finally have a cure. Thanks to modern biotechnology, diseases that used to kill people, like smallpox, measles, and even HIV may actually hold the key to killing cancer. The ability for a virus to infect cancer cells has been documented as early as the 1900s. Recently scientists have been able to manipulate the genetic structure of viruses so we can use them to treat cancer safely.

Functionalism Free Essays

Functionalism is the doctrine that what makes something a mental state of a certain type depends on the way it functions, or the role it plays and not on its internal structure. Simply put, functionalism gives utmost importance to the function or role a mental state plays. They also give prime importance to causal relations because according to the follower of this doctrine any form of mental state is â€Å"†¦determined by its causal relations to sensory stimulations, other mental states and behaviors. We will write a custom essay sample on Functionalism or any similar topic only for you Order Now † (http://plato.stanford.edu/entries). Let me take â€Å"pain† as an example. For the functionalist, pain is a mental state which arose because of a damage of some kind or because something is wrong with the body. For them, the only beings that could possibly experience pain are those who qualified to meet the condition stated above. However, the functionalists did not claim that there are only limited states of affair on which pain can be experienced. For them, various creatures may experience pain through different kinds of physical or mental states and thus the term multiple realizations came into context. Having defined what functionalism is, let me now move on to another important aspect of this paper-dualism. Dualism came from the Latin word dualis which means two. It is the belief that in everything in this world two important concept, which usually oppose each other exist. Just as there is a night then there must be a day. When there is good, there is evil. Such is the basis on which dualism is grounded.   In the philosophy of mind dualism aims to show the great difference there is between mind and matter. There are many differing points of view between the dualists themselves but they stood on the common ground that mind and matter are indeed distinct objects. According to the dualistic point of view where mind is made up of non-physical substance, our body is made-up of physical ones commonly known as matter. The mind and body dualism can be deduced as substance dualism which argues that mind and body are made-up of entirely distinct substances, and by property dualism which asserts that the mind and body may not be made-up of distinct substances but still, they are distinct and thus we cannot reduce one from the other. Now, how does functionalism differ from dualism? Functionalism is different from dualism because functionalism does not adhere to the idea of interactionism unlike that of dualism. Most believer of substance dualism argues for the sake of interactionism or the belief that mind and body, though distinct from each other, are still capable of causally affecting each other. Believers of the identity theory believe that there are at least some kinds of mental states which are completely identical to those of brain states. One known proponent of this theory is David Armstrong who proposed that â€Å"all mental states are identical with physical states†. This theory argues that the mind is indistinguishable from the brain. Due to their approach and beliefs regarding the mind they received numerous objections among which include the argument from multiple realizability. Believers of multiple realizability argues that mental events differ considerably from one organism to another and thus the idea that certain mental events are the same most of the timeis kind of preposterous. Thus functionalism and identity theory is very different from each other. Functionalism is considered to be more superior to other theories of mind such as dualism and the identity theory. Now, what brought about this superiority? Functionalism argues that everything is physical. The functionalists, unlike the other theories of the mind can do away without knowing how the brain came about its consciousness. The functionalists are satisfied to simply say that the function of our brain is to be conscious or consciousness. They do not put great effort in discovering what causes the consciousness of our brain which made them superior from the other mind theory. Another advantage functionalism may have over the other theories is its ability to equate conscious states with the functions of our brain, thus functionalism allows examination of our conscious states which plagues other theories. I said that it plagues other theories because they give too much privacy to matters of mind, believing that mind is a private matter and thus cannot be compared to other minds (such as the problem in Cartesian dualism). Functionalism, on the other hand faces no such problems because they give way to analyzing other minds or other experiences. The ability to test things empirically offered by functionalism shows its edge against dualism and the identity theory of the mind. Another advantage functionalism has over dualism and the identity theory of the mind is that the theory of functionalism offers understanding of the mind. However, no matter how great functionalism may be as compared to other mind theories it still has its drawbacks. It does not entirely solve the problems of the mind. Functionalism does not give us a clear explanation of the obvious distinction of the physical and conscious states. Besides, another objection arose from their claim that we can really differentiate one mind from the other. Surely, no one can fully understand how other minds work. Besides different people experiences things differently no matter how alike their experience may seem. For example, I may feel deep depression upon losing a pet but then I cannot really say that the depression Anne felt when she lost her dog is the same as mine, now could I? Thus, no matter how more advantageous functionalism may be over dualism and the identity theory it is still not wise to go on believing functionalism as a whole. One must still see the pros and cons of certain thoughts or theories. REFERENCES: â€Å"Assess functionalism† â€Å"Dualism and Mind† â€Å"Identity Theory† http://www.utm.edu â€Å"Functionalism† http://plato.stanford.edu/entries    How to cite Functionalism, Essay examples

Manufacturing Industry Process Improvement -Myassignmenthelp.Com

Question: Discuss About The Manufacturing Industry Process Improvement? Answer: Introduction A particular measuring scale must be used that determines the quality of education provided by the schools. The knowledge absorption level of each student needs to be evaluated for his or her benefit as well as for the benefit of the schools. Every student is unique and the structure of the education must be centred on that concept. However, each teacher has his or her own teaching style and ability. The education structure must not put a limitation on that. The purpose of this report is to develop some quality control benchmark by studying the seven quality control tools. These tools will facilitate the development of a continuous improvement plan that could be utilized to improve the quality of education. This report contains elaborations on seven basic quality control tools, their descriptions and the two best tools among those that can be used to accomplish the expected goal. A well-structured improvement plan is also provided in this report along with a detailed implementation p lan. Tools and Techniques Available for Cause Determination David can use Root Cause Analysis for cause determination of the problems associated with the quality of education (Geerling, Chernofsky and Pratt 2014). This type of analysis can be used to determine the primary cause or the root cause associated with a problem. The cause is termed as root if the removal of the cause would solve the problem associated with the case (Raghavan 2015). David must evaluate the process and not just the people. This technique will help David to identify the flaws underlying the process where the students rates the performance of the teachers and the absence of any student attendance database. Quality Control Tools Seven quality control tools can be used to determine, assess and analyse the different quality control scenarios. Cause-and-effect diagram: This diagram is primarily used for product designing and prevention of any defect in the manufactured products. The causes are generally categorized into different groups that would aid in identifying and classifying different sources of cause variation (Dirnagl 2016). Categorising causes means that their identification is simplified in the event of any problem occurrence. The cause-and effect diagram is also known as fishbone diagram due to the utilization of the categorising concept. Check Sheet: Real-time data is collected at the data generating location in this scenario. The collected data can be either qualitative or quantitative (Sharma and Suri 2017). The person collecting the data, the collected data, the place and time of data collection and the reason for data collection are all implicated in the check sheet. The sheet is also known as tally sheet if it contains only quantitative data. The check sheet can be used to identify defects and understand the source of their occurrence by identifying the causes. Every problems and their respective causes are marked on the sheet and at the end of the assessment, the problem with the most marks are evaluated with the most priority. Control Chart: It is a type of chart where a graph is created based on the statistical findings where a chart is developed based on the process and the behaviour values (Magar and Shinde 2014). This tool can be used to determine and control any business or manufacturing process. Standard deviation is calculated using the data collected. The deviation would show any abnormality in the production or business process. This information can then be used to implement different methods that would help to control the operations and the processes. Histogram: This is a bar graph that helps to visualize the collected numerical data. A histogram is basically used for plotting continuous data (Arnold and Tilton 2015). Such graphs can be used to give precise reflection upon the data collected. The flaws in the processes can be rectified based on the data collected. Pareto Chart: This chart is a combination of a bar graph and a line graph. A Pareto chart can be used to specify the most common set of factors in quality control (Magar and Shinde 2014). The defects that occurs most commonly are identified and then the cause that primarily causes these defects. The causes are stated in decreasing order to show the defect that is commonly encountered. Since more than two graphs and three axes are used together to demonstrate the data, various aspects can be covered that could be utilized to analyse any number of flaws and their sources. Scatter Plot: A scatter plot can be used to map out data that is related either to one independent variable or between two independent variables. The data is seen as positively correlated if the dot pattern starts at the lower left side of the graph and ends at the higher right side (Manly and Alberto 2016). The data is seen as negatively correlated if the pattern of the dots starts at the upper left side and slopes down to the lower right side of the graph. This type of plot is generally used for quality control when the collected data has a non-linear relationship between them. Stratified Sampling: This type of quality control tool can be used where one sample is divided into multiple mutually exclusive homogeneous subgroups. Such a tool is used for population estimation (Jing, Tian and Huang 2015). Two tools that are best suited for application by David are as follows: A histogram can be used to analyse and evaluate the ratings given by the students to their teachers. As discussed, a histogram can be used to gather a huge collection of data. The data gathered from the students can then be used to determine the root cause of the problem (Latino, Latino and Latino 2016). The teachers must be interviewed separately to determine the authenticity of the collected data. The data collected through this technique must be anonymous in nature and should never be revealed by the school management under any circumstances. A Pareto Chart can be used to collect attendance information and examine the results of the analysis. The chart, as discussed, can depict attendance information in the line graph and the reasons for absence can be depicted in the bar graph. The most common reason can be viewed and a precise solution can be provided depending on the scenario and the reason of absence. Continuous Improvement Plan A continuous improvement plan is thus given in this section of the report that would help David to improve on the flaws of the school system. Issue Identification Date Issue Identified and Improvement Action Required Person or People Responsible Required by Date Expected Outcome and Date of Closure Review Date 14/1/2018 The feedback rating provided by the students to their teachers does not reflect the actual scenario. The management of the school must conduct the collection of the data to prevent any data manipulation by either the teachers or the students. The histogram style of quality control is seen as the best graphical style of data analysis in this scenario (Gelman 2014). The ratings must be then evaluated by a select board of members, constituting of David and four other people from the management, responsible for quality control in the school. David and the committee members. Data collection-25/1/2018. Finishing the interviews based on the data- 28/2/2018. The data collected on teacher review would be almost accurate with a 5% chance of error. The closure date should be around 6/3/2018. 2/3/2018 14/1/2018 Attendance information of the student was never documented. An electronic database can be used to save the attendance information of the students. Storing the information digitally would help David to analyse the situation easily. David 1/3/2018 Easy access to the attendance data collected. The closure date should be around 1/4/2018. 15/3/2018 14/1/2018 Applying the Pareto Chart technique to visualize the attendance of the students and understand the details behind their reasons for absence. David and the committee members. 1/5/2018 Better understanding of the reasons for student absence and the methods to handle them. The closure date should be around 10/5/2018. 5/5/2018 Implementation Plan Organizational Approval: The key stakeholders are identified (Lawrence and Weber 2014). They are presented with the ideas of quality control and the need for the application of the quality control tools. Approval of the implementation plan. Committee Development: David and some members from the management body of the school who would process. Data Needed: The feedback of the students regarding their teachers. The attendance of the students. Review Plan: Analysing the collected data and preparing the solution based on the sole discretion of the committee members. Positive result must be ensured. In case of any unfavourable results, the process can be scrutinized for execution errors (Soeanu 2016). Difficulties in Implementing the Proposed Plan The difficulties that might be faced during the implementation of the proposed plan: Teachers have a strong influence on students especially those belonging to the junior classes. They can easily manipulate the feedback process. Some of the teachers might raise objections against the anonymous feedback process. Getting bad reviews would mean that their appraisals might be hindered and even their promotion in some cases. The individual teacher interview process follows the feedback system. This interview process is time consuming and thus some teachers might view it as a waste of time. The documented attendance system would mean that the students would not be able take any unauthorized leave of absence. The student and their respective parents might find that a problem and can create objections during the plan implementation process. Long-Term Benefits of the Proposed Continuous Improvement Plan The proposed continuous improvement plan would significantly benefit the school and its students in the long term. The benefits are as follows: The anonymous feedback system would help to improve the performance of the teachers significantly. The teachers would not be able to manipulate the feedback of the students. All the feedback would be accurate. The students would feel at ease while giving the reviews as it is anonymous. This would drive the teachers to provide quality education to the students (Southerland, Gadsden and Herrington 2014). Any form of incentive to manipulate the feedback process is pointless, as the management would never share the details of the review. The students might or might not give positive feedback even after receiving the incentive. The interview process after the feedback system would also be beneficial as the teachers would be able to state justification to any bad feedback from the students. There can also be times where the student might give false bad review. This can be easily highlighted and scrutinized in the interview process. The student can even be penalized depending on the severit y of the false review. Quality control in the education sector is of prime importance and an efficient review system would definitely help to boost the system. A documented attendance system would also be productive for the school system. The students would be punctual and would not be absent without any authentic reason. Regular attendance by the students would mean that they would not be missing any important lectures. Thus, the quality of the education is improved too. The students are involved in continuous lectures in sequence and thus their understanding of the subjects improve drastically. Conclusion Thus, it can be concluded that the concerns of David regarding the school education system is justified. The quality of education has been gradually going downhill due to lack of teacher-student involvement and enthusiasm for the process. The teachers are not motivated enough to provide the sufficient quality of education. Thus, they fail to motivate the students to be interested in the education process. Due to this, the students lose interest in coming to schools and get the fundamental education needed. The continuous improvement plan discussed in the report would definitely help to improve the education quality. However, it is a long-term process and must be treated as one. The implementation plan also included in the report would be helpful in applying the improvement plan. The problems that might be faced by the school committee while implementing the quality control plans is provided in the report. The report finally concludes with the long-term benefits of the implemented pla ns and the gradual improvement in education quality. Reference List Arnold, T. and Tilton, L., 2015. EDA I: Continuous and Categorical Data. In Humanities Data in R (pp. 25-46). Springer International Publishing. Dirnagl, U., 2016. Quality Control and Standard Operating Procedures. Rodent Models of Stroke, pp.291-300. Geerling, J., Chernofsky, M. and Pratt, S.D., 2014. Root Cause Analysis. ASA Newsletter, 78(6), pp.46-49. Gelman, A., Carlin, J.B., Stern, H.S., Dunson, D.B., Vehtari, A. and Rubin, D.B., 2014. Bayesian data analysis (Vol. 2). Boca Raton, Jing, L., Tian, K. and Huang, J.Z., 2015. Stratified feature sampling method for ensemble clustering of high dimensional data. Pattern Recognition, 48(11), pp.3688-3702. Latino, R.J., Latino, K.C. and Latino, M.A., 2016. Root cause analysis: improving performance for bottom-line results. CRC press. Lawrence, A.T. and Weber, J., 2014. Business and society: Stakeholders, ethics, public policy. Tata McGraw-Hill Education. Magar, V.M. and Shinde, V.B., 2014. Application of 7 Quality Control (7 QC) Tools for Continuous Improvement of Manufacturing Processes. International Journal of Engineering Research and General Science, 2(4), pp.364-371. Magar, V.M. and Shinde, V.B., 2014. Application of 7 Quality Control (7 QC) Tools for Continuous Improvement of Manufacturing Processes. International Journal of Engineering Research and General Science, 2(4), pp.364-371. Manly, B.F. and Alberto, J.A.N., 2016. Multivariate statistical methods: a primer. CRC Press. Raghavan, A., 2015. Root cause analysis. In Management and LeadershipA Guide for Clinical Professionals (pp. 105-121). Springer International Publishing. Sharma, H. and Suri, N.M., 2017. Implementation of Quality Control Tools and Techniques in Manufacturing Industry for Process Improvement. Work, 4(05). Soeanu, A., Debbabi, M., Allouche, M., Blanger, M. and Lchevin, N., 2016. Hierarchy aware distributed plan execution monitoring. Expert Systems with Applications, 43, pp.66-81. Southerland, S.A., Gadsden, V.L. and Herrington, C.D., 2014. Editors introduction: What should count as quality education research? Continuing the discussion. Educational Researcher, 43(1), pp.7-8.

Teen Problem Essays - Adolescence, Educational Psychology

Teen Problem My assigned lot in life is that of the mother of a fifteen-year-old son. My son has not yet gone through the growth spurt that always accompanies adolescence. I can imagine that as my son, I would feel extremely self-conscious at all times. Speaking from experience, it`s hard to be so different than all your classmates are. Many high-school students dislike having distinguishing features that set them apart from the rest, such as being short. These features can be the basis for a lot of teasing and humiliation. Being a female, I don`t have any first-hand experience dealing with a male`s perspective, but I would think it would be even harder to be a short boy. Males in our society are stereotypically strong and muscular. Rarely do we see couples in which the wife is taller than the husband. My son must feel humiliated by his peers because he does not fit the "masculine mold". Teenagers are very impressionable. They are still trying to form their own identity, separate from that of their parents. Most adolescents want to be a person that everyone else likes and accepts, and some will take drastic measures to be just that. It could get to a point where my son would try to take some sort of growth supplement from the back cover of a magazine, which would not be a healthy idea. Teenagers often have such a burning desire to fit in that they hate themselves when they cannot. I say all of this from experience, currently going through "the best years of my life" right now. The thing to remember, though, is that everyone grows at a different rate, and not everyone is truly laughing at you. This information will be extremely hard for my son to believe, because I as a teenager myself still don`t get it. When you walk into a room, it is impossible for everyone to be staring at you and laughing about your appearance, because they are too worried about themselves! Teenagers don`t often realize that many of their peers feel just as uncomfortable in their own skin as they do. For my role as a mother, I think I need to be as supportive as possible. It can be a very detrimental thing for a teenager to feel like he doesn`t belong anywhere and that no one likes him, leading to drugs, alcohol, even death. I need to find out what my son needs and do my best to provide it for him, without turning him into a spoiled child. The best thing for a person who is upset is a loving, caring individual who supports him. However, none of this support can be shown in public. Adolescence is the time of natural separation from one`s parents, a time when parents begin to be "uncool" and "embarrassing". To show any sort of affection in front of his friends would make my son feel even worse. This would only be yet another thing that would set him apart from his peers (or at least he would think so). Overall, the fact that my son has not yet received his growth spurt will probably be viewed as a negative thing. He will be unhappy and teased by his friends for not appearing masculine, and this could lead to disastrous results. To prevent any of these happenings, I will try to be a loving, caring, supportive parent, although not in public, for I feel that would simply make it worse. The situation, however, could turn out to be very positive. When all of his friends have stopped growing, my son may shoot up past every one of them. We will not know how this turns out, however, for at least a few years, at which point it will probably be less of a problem. As a poster I once saw states (paraphrased), "The problem, once solved, is simple".

An Interview with Publishizer Founder Guy Vincent

An Interview with Publishizer Founder Guy Vincent Putting Readers First - An Interview with Publishizer’s founder Guy Vincent Crowdfunding is possibly one of the evolutions in publishing that is most exciting to independent authors who are serious about their work. It turns the traditional publishing model upside down, with readers basically funding the books before they are published, and authors finding an audience before even finishing the manuscript. Last year, we hosted a fascinating interview with Maris Kreizman, from Kickstarter publishing, on how authors could use Kickstarter to, well†¦ â€Å"kickstart† their next book. Today, we’re interviewing a smaller player - but just as exciting!In the past few months, we’ve been impressed by the quality of the projects on the Publishizer platform, as well as the amounts raised (take a look at their â€Å"ended campaigns† here), so we’ve decided to interview the founder, Guy Vincent. He’ll tell you just as useful Publishizer can be for your next book!The print run of Mobile Ready, Publishizer’s first success storyDo certain genres work better than others on Publishizer?It’s still early days for our startup. We started out focusing on startup and business topics, since that’s the community where I had the most connection to writers. Early on we attracted cookbooks, children’s books and a few novels.We can see tha t business authors have a natural tendency to understand having a target reader, marketing plan and publishing strategy. Our business authors are paving the way to help us build our own audience, who we can eventually help to bring them books in other genres they might be interested in, such as fiction.Our authors are encouraged to think of their book as a startup. That means having an entrepreneurial and creative spirit when it comes to promoting their work, experimenting with different marketing tactics and learning what works best for their audience.Authors who have successfully completed a pre-orders campaign on Publishizer can either go on to self-publish, or submit their book proposal to traditional publishers. Now, if you have money and an established reader base, why would you want to sign with a traditional publisher? What more can they offer?Self publishing offers wondrous opportunities for authors, however, it can also be time consuming and some authors might prefer to ha nd over their work to a publisher who can take care of the nitty gritty details.Publishizer helps authors activate and expand their existing audience, and publishers can potentially take the book to the next level through wider distribution channels. There is also still a perceived credibility to having a traditional publisher. If we can help our authors attract the right kind of publisher to bring their book higher up the value chain, we’ll do our best to support this.You insist on the importance of quality cover art, and say it should be left to the professionals. Would you agree that the explosion of self-publishing, where authors have limited budgets, is endangering the quality of graphic design in books?We see a clear parallel with authors who insist on high quality cover artwork and the success of their Publishizer campaign. There are plenty of tools and resources available to allow authors to get a professional looking front cover, without spending much (if anything) u pfront.After a successful preorders campaign, with money in the bank, we notice our authors who go on to become bestsellers really invest in their editing and design, to make their book the best it can be. Professional quality editing and design often doesn’t come cheap, and this is where preorders makes it possible for authors to afford the best services for their book.I feel we’re heading into the golden age of self publishing, where authors have access to the world’s best editing, design and marketing talent. In the future, books won’t be ‘self published’, they’ll be the artistic creation of writers who activated their audience, and hired the best talent to bring their vision to reality. We hope Publishizer can be a part of that vision.And we share that hope. Thanks a lot for your time, Guy!  Follow Publishizer and Reedsy on Twitter:  @publishizer  and @ReedsyHQ  Have you tried a crowdfunding platform for a publishing projec t? Do you also feel like we’re heading into the golden age of self-publishing? Leave us your thoughts, or any questions for Guy, in the comments below!

Battle of Ia Drang in the Vietnam War

Battle of Ia Drang in the Vietnam War The Battle of Ia Drang was fought November 14-18, 1965, during the Vietnam War (1955-1975) and was the first major engagement between the US Army and the Peoples Army of Vietnam (PAVN). After a North Vietnamese strike against the Special Forces camp at Plei Me, American forces deployed in an effort to destroy the attackers. This saw elements of the air mobile 1st Cavalry Division move into South Vietnams Central Highlands. Encountering the enemy, the battle was primarily fought at two separate landing zones. While the Americans won a tactical victory at one, they took heavy losses at the other. The fighting in the Ia Drang Valley sent the tone for much of the conflict to come with the Americans relying on air mobility, air power, and artillery while the North Vietnamese sought to fight at close quarters to negate these advantages. Fast Facts: Battle of Ia Drang Conflict: Vietnam War (1955-1975)Dates: November 14-18, 1965Armies Commanders:United StatesColonel Thomas BrownLieutenant Colonel Harold G. MooreLieutenant Colonel Robert McDadeapprox. 1,000 menNorth VietnamLieutenant Colonel Nguyen Huu Anapprox. 2,000 menCasualties:United States: 96 killed and 121 wounded at X-Ray and 155 killed and 124 wounded at AlbanyNorth Vietnam: Approximately 800 killed at X-Ray and minimum of 403 killed at Albany Background In 1965, General William Westmoreland, commander of the Military Assistance Command, Vietnam, began utilizing American troops for combat operations in Vietnam rather than solely relying on the forces of the Army of the Republic of Vietnam. With National Liberation Front (Viet Cong) and Peoples Army of Vietnam (PAVN) forces operating in the Central Highlands northeast of Saigon, Westmoreland elected to debut the new air mobile 1st Cavalry Division as he believed its helicopters would allow it to overcome the regions rugged terrain. Ia Drang - Vietnam. US Department of Defense Following a failed North Vietnamese attack on the Special Forces camp at Plei Me in October, the commander of the 3rd Brigade, 1st Cavalry Division, Colonel Thomas Brown, was instructed to move from Pleiku to seek and destroy the enemy. Arriving in the area, the 3rd Brigade was unable to find the attackers. Encouraged by Westmoreland to press towards the Cambodian border, Brown soon learned of an enemy concentration near Chu Pong Mountain. Acting on this intelligence, he directed the 1st Battalion/7th Cavalry, led by Lieutenant Colonel Hal Moore, to conduct a reconnaissance in force in the area of Chu Pong. Arriving at X-Ray Assessing several landing zones, Moore chose LZ X-Ray near the base of the Chu Pong Massif. Roughly the size of a football field, X-Ray was surrounded by low trees and bordered by a dry creek bed to the west. Due to the relatively small size of the LZ, the transport of the 1st/7ths four companies would have to be conducted in several lifts. The first of these touched down at 10:48 AM on November 14 and consisted of Captain John Herrens Bravo Company and Moores command group. Departing, the helicopters began shuttling the rest of the battalion to X-Ray with each trip taking around 30 minutes. Soldiers of the U.S. Amry 1/7th Cavalry disembark from a Bell UH-1D Huey at LZ X-Ray during the battle of Ia Drang. US Army Day 1 Initially holding his forces in the LZ, Moore soon began sending out patrols while waiting for more men to arrive. At 12:15 PM, the enemy was first encountered northwest of the creek bed. Shortly thereafter, Herren ordered his 1st and 2nd Platoons to advance in that direction. Encountering heavy enemy resistance, the 1st was halted though the 2nd pushed on and pursued an enemy squad. In the process, the platoon, led by Lieutenant Henry Herrick, became separated and was soon surrounded by North Vietnamese forces. In the firefight that ensued, Herrick was killed and effective command devolved to Sergeant Ernie Savage. As the day progressed, Moores men successfully defended the creek bed as well as repelled assaults from the south while awaiting the arrival of the remainder of the battalion. By 3:20 PM, the last of the battalion arrived and Moore established a 360-degree perimeter around X-Ray. Eager to rescue the lost platoon, Moore sent forward Alpha and Bravo Companies at 3:45 PM. This effort succeeded in advancing around 75 yards from the creek bed before enemy fire brought it to a halt. In the attack, Lieutenant Walter Marm earned the Medal of Honor when he single-handedly captured an enemy machine gun position (Map). Day 2 Around 5:00 PM, Moore was reinforced by the lead elements of Bravo Company/2nd/7th. While the Americans dug in for the night, the North Vietnamese probed their lines and conducted three assaults against the lost platoon. Though under heavy pressure, Savages men turned these back. At 6:20 AM on November 15, the North Vietnamese mounted a major attack against Charlie Companys section of the perimeter. Calling in fire support, the hard-pressed Americans turned back the attack but took significant losses in the process. At 7:45 AM, the enemy began a three-pronged assault on Moores position. With the fighting intensifying and Charlie Companys line wavering, heavy air support was called in to halt the North Vietnamese advance. As it arrived over the field, it inflicted major losses on the enemy, though a friendly fire incident led to some napalm striking the American lines. At 9:10 AM, additional reinforcements arrived from the 2nd/7th and began reinforcing Charlie Companys lines. By 10:00 AM the North Vietnamese began withdrawing. With fighting raging at X-Ray, Brown dispatched Lieutenant Colonel Bob Tullys 2nd/5th to LZ Victor approximately 2.2 miles east-southeast. Moving overland, they reached X-Ray at 12:05 PM, augmenting Moores force. Pushing out of the perimeter, Moore and Tully succeeded in rescuing the lost platoon that afternoon. That night North Vietnamese forces harassed the American lines and then launched a major assault around 4:00 AM. With the aid of well-directed artillery, four assaults were repelled as the morning progressed. By mid-morning, the remainder of the 2nd/7th and 2nd/5th arrived at X-Ray. With the Americans on the field in strength and having taken massive losses, the North Vietnamese began withdrawing. Ambush at Albany That afternoon Moores command departed the field. Hearing reports of enemy units moving into the area and seeing that little more could be done at X-Ray, Brown wished to withdraw the remainder of his men. This was vetoed by Westmoreland who wished to avoid the appearance of a retreat. As a result, Tully was instructed to march the 2nd/5th northeast to LZ Columbus while Lieutenant Colonel Robert McDade was to take the 2nd/7th north-northeast to LZ Albany. As they departed, a flight of B-52 Stratofortresses was assigned to strike the Chu Pong Massif. While Tullys men had an uneventful march to Columbus, McDades troops began encountering elements of the 33rd and 66th PAVN Regiments. These actions culminated with a devastating ambush in the vicinity of Albany which saw PAVN troops attack and split McDades men into smaller groups. Under heavy pressure and taking major losses, McDades command was soon aided by air support and elements of the 2nd/5th which marched in from Columbus. Beginning late that afternoon, additional reinforcements were flown in and the American position was appearance during the night. The next morning, the enemy had largely pulled back. After policing the area for casualties and dead, the Americans departed for LZ Crooks the next day. Aftermath The first major battle that involved US ground forces, Ia Drang saw them suffer 96 killed and 121 wounded at X-Ray and 155 killed and 124 wounded at Albany. Estimates for North Vietnamese losses are around 800 killed at X-Ray and minimum of 403 killed at Albany. For his actions in leading the defense of X-Ray, Moore was awarded the Distinguished Service Cross. Pilots Major Bruce Crandall and Captain Ed Freeman were later (2007) awarded the Medal of Honor for making volunteer flights under heavy fire to and from X-Ray. During these flights, they delivered much-needed supplies while evacuating wounded soldiers. The fighting at Ia Drang set the tone for the conflict as American forces continued to rely on air mobility and heavy fire support to achieve victory. Conversely, the North Vietnamese learned that the latter could be neutralized by quickly closing with the enemy and fighting at close range.

Evaluate the role of the line manager in managing under-performance Essay

Evaluate the role of the line manager in managing under-performance - Essay Example bination of interpersonal and technical skills while for medical doctors the term ‘performance’ is depended rather on specific financial and administration skills’ (Nelson and Quick 2010, p.196). It is assumed that under performance reflects the lack of the skills that are necessary for responding to the needs of a particular role. Dowling, Festing and Engle (2008) tried to identify the key elements of under performance in regard to expatriates. They came to the conclusion that for expatriates, failure, which incorporates under performance, means ‘the premature return of an expatriate’ (Dowling, Festing and Engle 2008, p.112). In accordance with this view, under performance can be used for highlighting the failure of an employee to complete successfully the tasks assigned to him. A similar definition of the term ‘under performance’ is included in the study of Scullion (2006). In accordance with the above researcher, the term ‘under performance’ should be defined as ‘assignment failure’ (Scullion 2006, p.60). This explanation of under performance may be inaccurate, i.e. it may not reflect the actual status of employee performance. Such risk exists in case that an employee failed to complete the tasks assigned to him but not because of his fault but due to facts or conditions that they could not prevented, like, for example, a strike. From a similar point of view, Werner and DeSimone (2008) noted that the term ‘under performance’, or else ‘poor performance’, is difficult to be clearly defined since it is likely to be related to different criteria. For example, the level of performance of an employee may be characterized as high in regarding to a specific position and as low regarding to another position. For this reason, it is suggested that... It is evident from the study that the development of the phenomenon of employee under performance in modern organizations has been related to many factors. In accordance with Hadikin and O’Driscoll employees are likely to under perform when the conditions in the workplace are hostile for them. Reference is made especially to bullying, as a problem expanded in most organizations worldwide. It is noted though that the response of employees to bullying is not standardized. Under certain conditions, bullying may not lead to employee under performance, if for example the employee involved decides to report the problem to the firm’s HR manager. From another point of view, Berman considers that employee under performance is not related to the conditions in the organizational environment but rather to the personal attitudes of employees. It is explained that employees who are likely to avoid taking initiatives in regard to critical organizational issues tend to under perform wh en having to face such conditions. Moreover, employees that believe in their capabilities and their potentials to respond effectively to the needs of all tasks assigned to them are not expected to under perform, in opposition with employees who believe that their performance can ‘be affected by factors outside their control’. On the other hand, Shields explained that when having to identify the causes of employees’ under performance managers should search both for personal reasons, such as the attitudes or the background of employees, and for external reasons, meaning the conditions of the organizational environment.

Sociology - Symbolic interaction and gay marriage Essay

Sociology - Symbolic interaction and gay marriage - Essay Example What is most significant is the fact that the society has to approve the same and not hold the gay men accountable for what they indulge within. There is a good amount of information available at hand which suggests the proper incorporation of the gay marriages within the society’s aegis. The other side of the issue suggests that the society does not quite accept such gay relationships. They believe that it is very strange to enter into such relationships because it would bring problems for the people who are spread in different areas of the world. The straight individuals feel that the gay relationships effectively mar their own linkages that they have with the people around them, and make the same look awry and skewed (Bell, 2009). This perspective has been reached upon with the passage of time as gay relationships have come on excessively in this day and age, and within different areas of the world more than anything else. The gay marriage is such an important part of the s ociety in the current times that one cannot look beyond the same. There have been immense comprehensions that have been reached upon which suggest the notion of people being against the same as well as the ones who believe it is the right of the individuals to pick and choose their own orientation.

Marxism and Education Essay Example for Free

Marxism and Education Essay The Marxist perspective of education in society can be very questionable because Marxist theorists such as; Louis Althusser, Bowles and Gintis, David Reynolds and Willis all seem to disagree with one another. The first thing I will write about are the strengths. The strengths about the Marxist view are it points out how ideology is transmitted within school via the hidden curriculum, how education legitimises class inequality, it points out the inequalities of both opportunity and outcome on the system and it exposes the myth of meritocracy. From these points I can tell that it tries to believe that teachers are a kind of agent who are trying to wrong the children. Louis Althusser believed that education is an ideological apparatus designed to control children by brainwashing them. Applying this idea allows the hidden curriculum to transmit values which are not intentionally designed to happen. With class inequality it shows that schools are planting a job title on children which will link to their background. For example, a kid from the working class may get a job working at a car manufactures, while a kid from upper class may get a job as a lawyer. But, this really exposes the idea of meritocracy where if you do well at school you will get a good job as a reward. Now, I will write about the weaknesses. The weaknesses are that many working class children do succeed in the education system. It overemphasises class and ignores other structural inequalities: ethnicity and gender, post-modernists would argue that education reproduces diversity not inequality and Marxists cant seem to agree with each other at all. From these points I can tell that Marxists believe that working class children are a lot less smarter than upper class people but actually this isnt true because you dont need to be a higher class to be smarter than anyone else it takes the person to be determined to do it themselves. Also, the teacher could show a lot more favouritism to a specific gender in the class like girls or just as easily be based on the colour of their skin. So, you could be the smartest person in the class but you may be a black girl and I may not pick on you. Post-modernists on the other hand also argue that education reproduces diversity meaning people may not be picked on because of their disability etc. Finally, my last point is that none of the Marxist theorists cant agree with each other because each theorist believes that their theory is correct and go out trying to criticise everyone else. For example, Bowles and Gintis were criticised by Willis stating that their research wasnt in depth enough but he could easily be criticised for only researching 12 boys.

Von Hippel-Lindau Syndrome :: essays research papers

Von Hippel-Lindau syndrome is one of over 7000 known inherited diseases. It is an autosomal dominant disease that affects about 10% of the population.1 The history of VHL reaches back to 1864 when scattered reports of knots of blood vessels known as hemangioblastomas on the retina surfaced and were written up by opthamolagists. Eugene Von Hippel, a German opthamologist is credited with discovering the familial nature of the disease, however Swedish pathologist Arvid Lindau was the one who suggested that these hemangioblastomas are part of a larger "angiomatus [involving knots of blood vessels] lesion of the central nervous system." Additional reports of affected small families confermed Lindau's theory. In 1964, Melmon and Rosen summarized all knowlege of the disease and coined the name "Von Hippel-Lindau." The invention of ultrasound aided detection in the late 1970's, and by the mid 1980's, MRI was commonly used for detection of angiomas on the spine. In 1 993, the VHL gene was located by researchers at the National Cancer Institute. Patients with VHL suffer tumors known as angiomas (they are referred to as hemangioblastomas when discussing the retina, brain, or spinal chord and pheochromocytomas when discussing the adrenal glands) consisting of tiny knots of blood vessels. These angiomas can occur in the brain, spinal cord, retina, adrenal glands, kidney, pancreas, and very rarely in the epididymis is men and the fallopian tubes in women. Based on these manifestations, scientists have identified two types of VHL: 1) without pheochromocytoma 2) with pheochromocytoma. VHL type 2 has further been divided into two subcatagories: 2a) without pancreatic cysts 2b) with pancreatic cysts. VHL type 1 is the most common form of the disease. Scientists have also identified trends in race associated with manifestations of VHL: French families are most likely to have pancreatic cysts, German families are most likely to have pheochromocytomas, and Japanese families are more likely to have kidney tumors2. When hemangioblastomas form in the retina, they start out very small and difficult to detect. They tend to grow around the equator of the retina (See Fig 1), far from the area of central vision. A very indepth opthamological examination is required to detect hemangioblastomastomas of the retina. Once discovered, there are two main options for treatment: laser surgery or cryotherapy (freezing). The goal of these treatments is to keep the hemangioblastomas from growing. Hemangioblastomas in the brain and spinal cord can be a bit more dangerous. Early signs of a growth in these areas may include back pain, headaches, numbness, dizziness, and weakness or pain in the arms or legs.

Limitations of interviews Essay

Despite the advantages associated with interviews, a number of limitations must also be acknowledged. For example they are time-consuming; one of the biggest weaknesses could be the ability to interview only a sample population, raising concerns with the generalization of findings. As a consequence, in this investigation, the use of multiple sources of data has been conceived to validate qualitative data, as the degree to which archival data, interviews, and document analysis converge makes the conclusions about the phenomenon more convincing. The Method in which Conclusions will be derived The most important issue in research is that the process of arriving at conclusions is not a sequential one. No conclusion can be drawn until there is a clear data display. The process of arriving at conclusions will be as shown in Figure 6 below (Miles. Huberman, 1994). Consequently, after having administered the questionnaires and collated the responses, the findings will be compared with review of literature to analyze the banking system in China and UK. Figure 6 Chapter 3 – Literature Review Literature on Banking in China. Banking China – General. Modern banking in China commenced with the establishment of the first Chinese bank based on western pattern of banking in 1897. (Cheng, 2003). The Chinese banking system however has undergone turbulence over the years due to historical upheavals in the country such as the invasion by the Japanese in 1937, the Second World War, the Communist Revolution, communist party rule and there after opening of the economy in the 1980’s and 1990’s. The era of 1927 to 1937 is regarded as the golden era of Chinese banking under the government of Sun Yat Sen. There after there have been many changes until the emergence of the present banking system. (Cheng, 2003). Chow (1994) has indicated that the principal player in the Chinese banking industry is the People’s Bank which has played an important role in the Chinese economy even after liberalization though its role has been relatively passive. The Chinese banking reforms were undertaken after the landmark decision during the Third Plenary Session of the Fourteenth Congress of the Chinese Communist Party on 11 and 14 November. (Chow). These reforms reversed the processes undertaken almost five decades earlier in December 1948 when the People’s Bank was established after consolidating a number of local banks such as the Huabei Bank, Beihai Bank and Xibei Farmer Bank. The China Banking Regulatory Commission was established to supervise the financial industry in March 2003, thus diluting the hold of the People’s Bank as a central bank established in 1983. The People’s Bank is supported by four principal state controlled banks of which Bank of China (BOC) is one of the largest entities. The OECD Economic Survey on China 2005 indicates that the government policy has provided adequate space for the growth of market forces to influence the economy and is now determining the prices, trade, and investment by foreign companies as well as the overall financial system. (OECD, 2005). These reforms have impacted the level of savings in the Chinese economy while at the same time providing for greater foreign investment. The report has called for greater reforms in the banking sector to ensure that the process of growth is carried forward. (OECD, 2005). Thus broadly it would be seen that Chinese banking industry is on a threshold of transformation. Literature on Bank of China Bank of China – General The Bank of China is one of China’s oldest banks which has had a significant role to play in China’s financial history. The Bank was established in 1912 under the Sun Yat Sen regime. It had an important part to play in the turbulent period of China’s history to include a constant flux in the economy, political change and revolutionary periods including wars. (About Bank of China,. 2006). In the beginning of the Communist era, in1949, it was nominated as the primary bank specializing in foreign exchange. Thus it was at the fore front of development of foreign trade, providing currency and credit facilities to a large variety of individuals and firms. (About Bank of China, 2006). In 1994, the Bank was converted to a state owned commercial bank thus in 2003, when the Chinese banking sector assumed velocity it greatly benefited Bank of China. In 2003 another initiative to convert it into a joint holding bank was undertaken, a process which was finalized in 2004 when it was incorporated as a joint stock commercial bank, thereby providing it the ability and the regulatory authority to provide a wide spectrum of services across a vast geographic area to include 27 countries and regions. It is stated to have 10000 domestic and 600 overseas operations. (About Bank of China, 2006).

Ambassadors in Pinstripes

Review of Ambassadors in Pinstripes: The Spalding World Baseball Tour and the Birth of the American Empire Thomas Zeiler, the author of Ambassadors in Pinstripes: the Spalding World Baseball Tour and the Birth of the American Empire, entertains and enlightens the reader through a descriptive journey of Albert Spalding’s efforts to introduce a World Baseball Tour. The bulk of Zeiler’s book is based off of periodicals, newspapers, magazines, and guides; which serves as the groundwork for his book.Albert Spalding is known as a leader; a manager of the Chicago White Stockings, a very successful manufacturer of sporting goods, and predominantly as an organizer of tours designed to popularize America’s â€Å"national game† abroad. Spalding’s world tour mission was to send two teams of professional well known players to Australia, Ceylon, Egypt, Europe, and the surrounding areas. His marketing techniques and goals for his all American team to play worldwid e was a model for many industries seeking to establish abroad relations.Sports participation also provides a common ground and is a way to unite without discrimination, such as the warring people of South Africa during the Apartheid. Through this successful tour, Spalding established the pattern of baseball’s close connection with globalization and to let the world know of America’s increasingly ambitious exceptionalism in the world. Sports as a tool of diplomacy came of age in the post-World War I world when it caught the attention of politicians and governments as a channel through which to conduct international relations.Across the globe sports have personified the ideologies of political policies in the 20th century and as we enter the 21st century, sports are becoming an essential part of the toolbox of a country’s public diplomacy. Sport events that host numerous foreign visitors have impacts on a country’s relationship with foreign publics. It†™s why organizations and governments seek to attach themselves to popular figures, teams, and events that enhance their standings in the eyes of others.The Olympics for example serves as a way to bring world nations together through international sports competitions and encourages further engagement, often in the form of economic benefits through participation and hosting. London is currently hosting the Olympics this year and in preparation back in 2009 the event was predicted to â€Å"provide economic gold at a time of economic need,† however hosting the Olympics is an extremely costly business with the upgrades, new sports facilities, and security that it will cost much, much more than expected.Spalding’s World Baseball Tour laid the roots of the new empire and exemplified the United States onto the world stage. It highlighted our country’s economic growth, the search for overseas markets, improvements in communication and transportation, and the rising cul tural interactions. Thomas Zeiler’s main emphasis is on the baseball players and their entourage as â€Å"tourists† who helped disperse American culture abroad and brought global influences back to their homelands.Thomas Zeiler concluded that because of the immense impact of the World Tour, it was the process of globalization of baseball that laid the structure of the growing American identity. Baseball was used to sell and export the American way. The game associated itself with the values of the American dream. In America’s foreign diplomacy, baseball was used to promote patriotism and nationalism. Sports have shown it has the power to heal old wounds. Sport in South Africa during the Apartheid, kept the multiple races and cultures that make up South Africa apart for nearly a century.Apartheid was a system of racial segregation enforced by white Afrikaners, who were the minority, over the indigenous majority. Rugby was the sport that took a mental toll on all South Africans and played a larger part in the victory of the anti-apartheid movement. The Rugby World Cup was one of the key moments that shaped the world’s impression of the new South Africa. The Rugby World Cup contributed significantly to the return of foreign investment in South Africa and strengthening of trade and other economic links that had been destroyed through the policies of apartheid and the subsequent boycotts and restrictions.The development of the industrialization and the use of resources from across the world created a gateway for Americans. Spalding’s initial mission paved the way for global integration opened the door to the sensational play of foreign participants in America’s national pastime. The mass appeal of sports like baseball provides the United States with a social â€Å"olive branch. † Baseball diplomacy helps break the ice between nations that are separated by cultural differences, monetary discrepancies and educational v ariances.Sports are relevant to the study of foreign relations because it is fundamentally concerned with power, and our sports culture that is driven by the media, boasted by advertising, bankrolled by industrialists, that it’s reflective of American society. It has played a huge role in projecting American influence abroad. Sports purpose is no longer limitied to entertainment; it is often intermingling with trade, business, and politics. Hopefully sports will continue as a feature of modern life that connects people and continents together.

How Popping Your Knuckles Works

How Popping Your Knuckles Works Do you pop your knuckles or do your joints crack when you work out or even get up out of a chair? Theres a simple scientific explanation for the phenomenon. To understand how the popping sound is produced, its helpful to know how joints work. How Joints Work Joints are where two bones meet. The ends of the bones are protected from rubbing against each other by caps of cartilage. If the joints werent protected, bone would grind against bone, which is painful as well as destructive. The articular cartilage is cushioned by viscous, clear synovial fluid, produced by a membrane that surrounds each joint. Synovial fluid lubricates joints, much like oil lubricates metal parts in your car engine, preventing hard parts from grinding themselves up. What Makes Joints Pop and Crack? When you pop your knuckles or crack any joint, youre pulling the bones in a joint away from each other. This opens up the space in the joint, reducing the pressure inside it. The lower pressure pulls gases dissolved in synovial fluid out of solution. When the oxygen and carbon dioxide become less soluble, they form bubbles. The pop you hear is the sound of bubbles forming, much like you hear bubbles form when you crack open a can of soda, lowering the pressure inside the can, so the dissolved carbon dioxide can form bubbles. Interesting Facts If you take an x-ray of a joint right after popping it, the bubble is visible. It increases the size of the joint about 15%. The bubble doesnt last forever, though. After about half an hour, the gases dissolve back into synovial fluid. Once you pop your knuckles, you cant pop them again right away, because you need dissolved gases to get the effect. Other pops and cracks in your joints that you can do over and over again most likely are ligaments snapping back into place. Is Popping Your Knuckles Bad for You? In either case, the popping sound may sound scary and annoy others, but there is no evidence that repeatedly cracking your joints is harmful. However, it may lead to weaker grip strength, possibly from stretching out the joint repeatedly.

Your Guide to a Successful Second Interview

Your Guide to a Successful Second Interview You’ve survived your first interview. Congratulations! And the hiring manager has called you back in for a second round. Congrats again! You must have done something right, right? But that doesn’t mean you don’t have to prepare as arduously for your second interview as you did for your first. First, understand this is not a guarantee you’ll get the job. If anything, the competition has narrowed and become more fierce. You can’t rest on your laurels yet. You have to fight! You’ll probably be sitting down with someone higher up on the food chain- sometimes a lot higher up- as well, so your preparation and your game have to be top notch. There’s a lot more pressure. The stakes are higher. But you have another, more targeted chance to prove you are the right candidate for the job.Step 1: StrategizeMake sure you know exactly what the job is- what it entails, who you’d be reporting to, etc. Then make sure you know who exactly will be interviewing you- and read up as much as you can on who they are. You’ll want to impress your interviewer(s) with your expansive knowledge of the industry/company/role, but not scare them away. Strike a good balance.Be sure to prepare a brand new list of questions you should be prepared to ask when that section of the interview comes up. Tailor your research to this job in particular, and reach out to your contacts to see if you can chat with anyone who works or has worked in that office. It’s not a bad time to figure out what really matters to you in a job- and make doubly sure you want this one, as you move closer to potentially getting it.Step 2: PlanThere are three types of interviews: one-on-one interviews with a department head, director, or even owner; panel interviews with a group of higher-ups (think firing squad); and group interviews where you’re being interviewed alongside your competition. Each requires a slightly different strategy, so be sure to k now going in which scenario to prepare for. Mock interviewing with friends or current contacts is always a good idea to make sure you’re on your game.Step 3: Ask QuestionsWhether you’re talking to a supervisor, an HR manager, or a potential future coworker, you’ll absolutely need some questions to ask. Prepare a ton and then choose the one that makes the most sense when you’re on the ground. Make a list of questions for each type of person- that way you won’t run into an HR rep and only have questions prepared for your would-be immediate supervisor. When in doubt, ask about a typical day in the office, the work culture, or whether there is potential for professional growth.Your Top 5 Tips for a Second InterviewNo matter which sort of interview you’re facing, or with whom, here are five great ideas to keep you at the top of the heap.1. Be respectfulEven if you think you should be speaking with someone higher up on the food chain, treat whomev er interviews you with utmost respect. Make eye contact, be pleasant, shake hands firmly and warmly. And get a business card. You’ll thank yourself come thank you note time!2. Assess and analyzeRemember, a second interview is also a chance for them to start selling you on the job. Keep an eye out for red flags. Try to get a sense of your potential future coworkers. Ask yourself how you would feel in this environment, with this team. Do you respect the people who would be your supervisors?3. PrepareAs we said before, you have to prepare even more for a second interview than a first. You’ll need more information about the nitty-gritty details of the job, as specifics are much more likely to come up. Do your homework. Show how much you know about the job and about the company and industry.4. BreatheIt’s easy to get so stressed that you hold your breath. Don’t! Figure out what you’re going to say going in, and try to get through it. Take a moment to in ternalize questions before answering so you really make use of your preparation.5. Be honestThis should go without saying, but it bears repeating: no long-term good will come of you telling your interviewer what they want to hear. Be honest about your skills and your needs and you won’t end up in a job you don’t want or can’t handle.

Same Sex Marriages and the U.S.Constitution Term Paper

Same Sex Marriages and the U.S.Constitution - Term Paper Example By turning marriage into something decided on by the law, the civil rights of people stand the risk of being violated. The civil rights of people are perhaps the largest part of the argument on the side of people that approve of same-sex marriages. Civil rights allow all people to be treated equally in their political and social endeavors. By denying them the opportunity to marry whomever they choose, they are being denied their civil rights, based on the definition of civil rights. Equality is not being observed when same-sex couple is denied the chance to marry; therefore, the civil rights of people are not only being violated, but they are not being properly upheld. Furthermore, â€Å"the Constitution may already have embedded in its wisdom, equal rights for all people, including gay people who want to get married.† The Constitution does not mention marriage directly, but it does point out that everyone should be treated equally. The Constitution of the United States does n ot define anything in regard to what marriage is, nor does it discuss the specifics of the people that are allowed to be married or those who are not. The only thing even remotely close to marriage in the U.S. Constitution is the concept of civil rights, which states the equality of all peoples. (Gerstmann, pg. 44). The U.S. Constitution may be mum on the topic of marriage, but the introduction of federalism has given each individual state the ability to make their own constitutions. As such, each state is able to make their own sets of rules or amendments, ones that can go against what is already written in the U.S. Constitution, essentially overriding the original Constitution. This has prompted many state governments to put a ban on same sex marriage or to otherwise have these unions be called by something other than a marriage. These states are going against the civil rights of its people. In only a few cases, states have approved of same sex marriage. In 1996, former President Bill Clinton signed into law the Defense of Marriage Act, which stated that the federal government defines a marriage as being between a man and a woman. While states could decide for themselves if they would recognize same sex unions, this law made it so that a same sex couple married legally in one state would not be recognized in a state that banned same sex marriages or did not recognize them as being lawful unions. This would cause many same sex marriages to be invalid should a married same sex couple decide to move. Again, the decision was still left up to the states, but Clinton made it clear where he and the federal government stood. The equality of people was, once again, shunted aside over someone else’s discomfort. The approval of same sex marriage took a different turn in 2003, during the case of Lawrence versus Texas, when the Supreme Court announced a new Constitution that would â€Å"prohibit state legislatures from treating homosexuality any differently than heterosexuality (Taylor).† This allowed marriage to find its way into the Constitution, seeming to favor more those that are for same sex marriages. By forbidding states to distinguish or make any notice of difference between homosexuality and heterosexuality, they were approving same sex marriage, as well as acknowledging the civil rights of Americans, which has always been the main component of rights when it comes to marriage. Also in 2003, the Massachusetts Supreme Judicial Court ruled

An essay about the right of habeas corpus in the context of the war on

An about the right of habeas corpus in the context of the war on terror - Essay Example Signing into law of the Magna Carta was occurred in 1215 by King John. It gained significant political and legal prominence during the preceding centuries. During the early 12th century, King John of England was hugely unpopular in his country and was at constant conflict with some wealthy oil barons. The archbishop of Canterbury, in an effort to protect the rights of the church and make the king and the barons be at peace, conceived the Magna Carta. Magna Carta turned out as the Great Charter of the Liberties. The Charter promised the protection of the church’s rights from interference either by the king or the rebel barons. It also promised the barons protection from unfair or illegal imprisonment and limitations to the feudal payments to the crown. A council of 25 barons were necessary for the implementation of the feudal payments (Davis, 2010). King Edward in 1297 later issued this charter in a bid to raise taxes for his indebted monarchial government and to win political support. Edward institutionalized it as part of the Statute Law hence Giving birth to the genesis of the Habeas Corpus. In the early 16th century, a prominent lawyer who was also a politician; Sir Edward Coke advocated for common law to override the authority of the king. In addition, the advocacy was for the establishment of a civilian power and extension of the civil liberties of the freemen (Halliday, 2010). Coke was instrumental in the drafting of the petition of right. This petition later formed the basis for the English constitution and allowed for specific liberties. Aside from limiting the king from invoking martial law during the times of peace, the petition of right also permitted prisoners to give their views in the circumstances where their detention was questionable. Habeas corpus in England originated among the powerful ruling elites whose intention was to put limitations on the powers of the monarchy.

The effect of mohammed ali on Arabic culture in Egypt i mean how Dissertation

The effect of mohammed ali on Arabic culture in Egypt i mean how mohammed ali make modern egypt education scholarships , - Dissertation Example Research Methodology Why Muhammad Ali? As Viceroy (alternately Wali, Khedive or Pasha) of Egypt 125 years earlier had a revolutionary impact on Egyptian society, politics and culture. He also established a dynasty in 1805 that would last for almost 150 years: A dynasty that would only end with the Egyptian revolution and establishment of a Republic in 1953. (Dodwell, 1977, passim.) The following discussion will focus on the first Muhammad Ali and his impact on Egypt and Egyptian development. Initially, a brief biography of the Viceroy will be presented. The body of the discussion will focus on his reforms to various aspects of Egyptian life such as the army, academia and administration. The concluding section of this discussion will assess the impact of these changes and their importance. Biography Muhammad Ali was born in 1769, in the Ottoman province of Kavala, which was located in present-day Greece. According to Encyclop?dia Britannica online his â€Å"ethnic background is unkno wn, though he may have been an Albanian and was certainly a Muslim and an Ottoman subject.†(n. d.) Historian Afaf Lutfi Al-Sayyid Marsot, argues that even his birthday is unknown and suggests that 1770 was his actual date of birth. He also argues that Muhammad Ali was not Albanian but Kurdish. (1984, pp 24-25) His father was a military leader for the governor of Kavala. Muhammad Ali sustained a rumour that his father died when he was very young and thenceforward the young man was raised by the governor.(Encyclop?dia Britannica online, n. d.) Again, Marsot disputes this tale and asserts that his father did not die until Muhammad Ali was a married man of 20. (1984, p. 25) Details are sketchy but he followed in his father's footsteps in the military while also dabbling in trading and in 1787 he married his first wife, a relative of the governor. (Encyclop?dia Britannica online, n. d.) The various versions of Muhammad Ali's early life are complex and contradictory. However, this p roposal and the subsequent dissertation will focus on his life after 1801 and his impact on Egyptian politics, culture and society. Therefore, these specific historical questions do not have a major impact on this discussion. However, these disputes do clearly establish that the historical record of Muhammad Ali (as it is present in both primary and secondary sources) must be closely assessed for veracity and accuracy. What is clear and undisputed is military experience and connections to the government led to his being dispatched in 1801 as an officer in a force of Albanians sent to Egypt by the Sultan to drive out the French, who had invaded the Ottoman province three years earlier. He was to succeed in a manner that far exceeded the Sultan's expectations or desire. Napolean and Muhammad Ali The French invasion of Egypt in 1798 by Napoleon Bonaparte's Army of Italy had numerous motivations. Personally and politically, his eye on control of all of France, Napoleon hoped to enhance his popularity and prestige. Further, he was accompanied by an army of scholars who were assigned to explore and document Egypt's natural and ancient history. The French were also exploring the possibility of constructing a 'Suez' canal to facilitate destruction of Great Britain's hold over India (Harten, 2003). Eventually, the British defeated the French in Egypt, but themselves evacuated in 1803 once the Napoleonic threat was eliminated. Muhammad Ali remained and and a

Effects of Multi-Walled Carbon Nanotubes (MWCNTs)

Effects of Multi-Walled Carbon Nanotubes (MWCNTs) Spectral analysis, thermal behavior, XRD and morphology study in synthesis of carbon nanotubes decorated by Cysteamine Or A simple and efficient procedure for synthesis of Thiolic Composite with use Oxide Multi Walled Carbon Nanotube Or A simple and efficient procedure for synthesis of composite thiol with use oxide multi walled carbon nanotube and sulfur Or Behnam Maazinejad, Hamidreza Sadegh, Imran Ali, Ramin Shahryari Ghoshekandi, Vahid Ali Abstract In this paper, the effects of multi-Walled carbon nanotubes (MWCNTs) were studied as supports for the synthesis of MWCNT-COOH-Cysteamine nanocomposite. At first Purification MWCNT in H2SO4 and HNO3, solved and the solution earned ultrasound was to attain the equilibrium temperature to functionalization of carboxylate multi walled carbon nanotubes (MWCNT-COOH). Then using Cysteamine hydrochloride and NHS and DMF and EDC and MWCNT-COOH the mixture was refluxing. The prepared on thiol derivatized nanocomposite were analyzed by X-ray Diffraction, Scanning electron microscope, FTIR spectroscopy, Transmission Electron Microscopes (TEM) and Thermogravimetric Analysis (TGA). Keywords MWCNTs, Carbon nanotubes, Functionalization, Cysteamine, Surface modification, Nanocomposite, Thiol, CNT 1. Introduction Nanotechnology is significantly impressive Science and Economy in the 21st century [1]. Carbon, in different forms, has been long used as the main constituent material of solid electrodes as a further too metal electrodes [2]. After the first Iijima elucidation of their structures in 1991 [3], carbon nanotubes have attracted considerable interdisciplinary interest [4]. Carbon nanotubes are promising additives for thermoplastics, due to their superior mechanical, thermal, magnetic and electrical properties [5]. To optimize the potential applications of carbon nanotubes, it is essential to modify the carbon nanotubes with functional groups and/or nanoparticles in order to integrate the carbon nanotubes into desired structures or attach suitable nanostructures to them [6]. Carbon nanotubes possess high flexibility, large aspect ratios (Normally >1000), unique internal structures, electrical conductivity, high chemical activity, low mass density, high electro active surface area, thermal stability and great mechanical strength [7]. CNTs have extraordinary electrical conductivity and heat conductivity and mechanical properties, they are probably the top electron field-emitter possible, and their material properties can accordingly approach closely the very high levels intrinsic to them [8]. Hence, CNT’s have received considerable attention for usage in chemistry and environmental remediation [9]. CNTs represent an exquisite class of nanomaterials that stepped into the nanomedicine arena not more than a decade behind [10]. The two main types of carbon nanotubes are the single-walled carbon nanotubes (SWCNT) and multi-walled carbon nanotubes (MWCNT), yet there are some other rare types such as fullerite, torus, and nanoknot [11]. Surface functional groups can modify the surface charge, functionality and reactivity of the surface, and increase the stability, and dispensability of Different materials [12-13]. Organic sulfur compounds are wide-spreading in numerous natural products and widely used as multiple artificial chemicals [14]. The structure and surface chemistry of organic thin films is a research region related to several interfacial processes, including biological events, lubrication, adhesion, wettability, corrosion, electrochemistry, and microelectronic fabrication. To acquire the optimum performance of a material or device in one of these applications, the organic thin film must be prepared with the right type, concentration, and arrangement of functional handle. Functionalization of carbon nanotubes is found to be an efficient way of modification processes which in public is divided in two main categories: noncovalent and covalent. Covalent functionalization is an irretrievable process of appendag e on the nanotube walls or tips it is based on the formation of a covalent coupling between functional entities and the carbon skeleton of nanotubes. Non-covalent functionalization is based on supramolecular complexation using different adsorption forces, such as van der Waals, hydrogen bonds, electrostatic force and Ï€-Ï€ stacking interactions. [57.15-55-56]. Thiols are the maximum reactive nucleophilic reagents among altogether the biological models investigated [16]. Thiol group is an alright ligand because of its strong affinity to various heavy metal ions as a result of Lewis acid–base interactions [17]. To various heavy metal ions as a result of Lewis acid–base interactions [3]. Thiol Derivatives paper Cysteamine an aminothiol, is used to decrease tissue cystine content in patients with nephropathic cystinosis, an autosomal recessive lysosomal storage disorder in which intracellular cystine accumulates due to impaired redeploy out of lysosomes [18]. Cysteamine is a sulfhydryl containing compound which appears to arise from the decarboxylation of cysteine or the breakdown of pantetheine [19]. Scheme 1. Is a schematic Cysteamine. [20] Scheme 1. Cysteamine Table 2: Structure and characteristics of Cysteamine [21] Cysteamine () is one of the simplest molecules able to bond with the each atoms surface through its sulfur and nitrogen atoms and a prerequisite for the design of compact monolayers with acceptable properties is a fundamental understanding of the forces captive in the self-assembly process, and the characterization of the film at the molecular level [22]. Cysteamine as drug applications that have been noted in the table 3 below: Table 3 In this study, we functionalized multi-walled carbon nanotubes with carboxyl group and thiol-derivatized via condensation reaction between carboxylated-MWCNT powders and Cysteamine. Infrared (IR) spectroscopy, XRD, SEM, TEM and TGA were used to characterize the presence of Cysteamine on the MWCNT-COOH surface. 2. Experimental Procedures 2.1. Materials Multi-walled carbon nanotubes (MWCNTs) with Purity 95 %, outer diameter and length and manufacturing method catalytic chemical vapor deposition were purchased from US Research Nanomaterials, Inc. Sulfuric acid (97 %, AR grade) and nitric acid (37%, AR grade) were purchased from Sigma-Aldrich. N,N-dimethylformamide (DMF:98%), 1-ethyl-(3-3’-dimethylaminopropyl) carbodiimide (EDC: 97%), N-hydroxysuccinimide (NHS: 99%) were purchased from Merck Millipore and Cysteamine hydrochloride (99%) were purchased from sigma Aldrich and used as received unless otherwise stated. 2.2 Characterization methods 2.2.1 X-ray diffraction (XRD) X-ray diffraction studies were carried out with an X-ray diffractometer (Model No. D8-Advance, Bruker AXS). 2.1.2 Fourier transform infrared spectroscopy (FTIR) The functional groups on the MWCNTs surface were determined using Fourier transform infrared FTIR method (VERTEX 70, Brucker). FTIR spectrum of MWCNTS was recorded in the range of 4000– 400 using pellets method. 2.2.3 Transmission electron microscopy (TEM) The morphologies and sizes of the nano-structures were characterized by transmission electron microscope â€Å"TEM† (PHILIPS EM 208). 2.2.4 Thermogravimetric analysis (TGA) Thermogravimetric analysis (TGA) was carried out using a TG Labsys DSC, Setaram. 2.2.5 Scanning electron microscope (SEM) The size and morphology of MWCNTs was investigated by high-resolution transmission electron microscopy (VEGA3, TESCAN). 2.3 Synthesis method At first [1] (1g) was treated with 20% hydrochloric acid for 120 min sonication, to remove impurities such as residual catalysts and amorphous carbons in the phase of synthesis , Then the sample was filtered with Millipore membrane filter 0.22 and washed many successive times with distilled water. 2.3.1 Oxidation of MWCNTs Multi-walled carbon nanotubes was synthesized by a formerly reported method [52-53]. 0.75 g of pristine MWCNTs was added to 180ml mixture of concentrated HNO3 and H2SO4 (1:3, v/v) and then ultrasonicated for a course of 140 min. then mixture was transferred to a flask equipped with a condenser and was refluxed with drastic shocking at 75 for 6 h. After cooling to Ambient temperature the mixture was filtered with filters paper and filtrated solid was washed thoroughly by deionized water until the filtrate pH was close to neutral. The filter sample was then dried in a vacuum oven at 80 oC for 120 min. The sample was abbreviated as MWCNT-COOH. 2.3.2 [1] Pavani, K. V., Gayathramma, K., Banerjee, A., Suresh, S. (2013). Phytosynthesis of Silver Nanoparticles Using Extracts of Ipomoea i ndica Flowers. American Journal of Nanomaterials, 1(1), 5-8. [2] Garcà ­a-Gonzà ¡lez, R., Fernà ¡ndez-La Villa, A., Costa-Garcà ­a, A., Fernà ¡ndez-Abedul, M. T. (2013). Dispersion studies of carboxyl, amine and thiol-functionalized carbon nanotubes for improving the electrochemical behavior of screen printed electrodes. Sensors and Actuators B: Chemical, 181, 353-360. [3] Sanagi, M. M., Hussain, I., Ibrahim, W. A. W., Yahaya, N., Kamaruzaman, S., Abidin, N. N. Z., Ali, I. (2014). Micro extraction of Xenobiotics and Biomolecules from Different Matrices on Nano Structures. Separation Purification Reviews, (just-accepted). [4] Sadegh, H., Shahryari-Ghoshekandi, R., Kazemi, M. (2014). Study in synthesis and characterization of carbon nanotubes decorated by magnetic iron oxide nanoparticles. International Nano Letters, 4(4), 129-135. [5] Mahmoodi, M., Arjmand, M., Sundararaj, U., Park, S. (2012). The electrical conductivity and electromagnetic interference shielding of injection molded multi-walled carbon nanotube/polystyrene composites. Carbon, 50(4), 1455-1464. [6] Zhang, Q., Zhu, M., Zhang, Q., Li, Y., Wang, H. (2009). The formation of magnetite nanoparticles on the sidewalls of multi-walled carbon nanotubes. Composites Science and Technology, 69(5), 633-638. [7] Mahmoodian, H., Moradi, O., Shariatzadeh, B. (2014). Grafting chitosan and polyHEMA on carbon nanotubes surfaces: â€Å"Grafting to† and â€Å"Grafting from† methods. International journal of biological macromolecules, 63, 92-97. [8] Moradi, O., Sadegh, H., Shahryari-Ghoshekandi, R., Norouzi, M. (2014). Application of Carbon Nanotubes in Nanomedicine: New Medical Approach for Tomorrow. Handbook of Research on Diverse Applications of Nanotechnology in Biomedicine, Chemistry, and Engineering, 90. [9] Bahrami, K., Khodaei, M. M., Soheilizad, M. (2009). Direct conversion of thiols to sulfonyl chlorides and sulfonamides. The Journal of organic chemistry, 74(24), 9287-9291. [10] Jain, S., Thakare, V. S., Das, M., Godugu, C., Jain, A. K., Mathur, R., Mishra, A. K. (2011). Toxicity of multi-walled carbon nanotubes with end defects critically depends on their functionalization density. Chemical research in toxicology, 24(11), 2028-2039. [11] Aqel, A., El-Nour, K. M., Ammar, R. A., Al-Warthan, A. (2012). Carbon nanotubes, science and technology part (I) structure, synthesis and characterisation. Arabian Journal of Chemistry, 5(1), 1-23. [12] Wang, Y., Iqbal, Z., Mitra, S. (2006). Rapidly functionalized, water-dispersed carbon nanotubes at high concentration. Journal of the American Chemical Society, 128(1), 95-99. [13] Saleh, T. A., Gupta, V. K. (2013). Covalent and Nonà ¢Ã¢â€š ¬Ã‚ Covalent Functionalization of Carbon Nanotubes.Advanced Carbon Materials and Technology, 317-330. [14] VukoviĆ¡, G. D., MarinkoviĆ¡, A. D., ÄŒoliĆ¡, M., RistiĆ¡, M. Ä ., AleksiĆ¡, R., PeriĆ¡-GrujiĆ¡, A. A., UskokoviĆ¡, P. S. (2010). Removal of cadmium from aqueous solutions by oxidized and ethylenediamine-functionalized multi-walled carbon nanotubes. Chemical Engineering Journal, 157(1), 238-248. [15] Castner, D. G., Hinds, K., Grainger, D. W. (1996). X-ray photoelectron spectroscopy sulfur 2p study of organic thiol and disulfide binding interactions with gold surfaces. Langmuir, 12(21), 5083-5086. [16] Holmgren, A., Sengupta, R. (2010). The use of thiols by ribonucleotide reductase. Free Radical Biology and Medicine, 49(11), 1617-1628. [17] Vieira, E. S., Simoni, J. A. (1997). Interaction of cations with SH-modified silica gel: thermochemical study through calorimetric titration and direct extent of reaction determination. Journal of Materials Chemistry, 7(11), 2249-2252. [18] Gahl, W. A. (2003). Early oral Cysteamine therapy for nephropathic cystinosis. European journal of pediatrics, 162(1), S38-S41. [19] Kuņºmierek, K., Bald, E. (2008). Measurement of reduced and total Mercaptamine in urine using liquid chromatography with ultraviolet detection. Biomedical Chromatography, 22(4), 441-445. [20] Reid, E. Emmet (1958). Organic Chemistry of Bivalent Sulfur 1. New York: Chemical Publishing Company, Inc. pp. 398–399. [21] Lukashin, B. P., Grebeniuk, A. N. (2000). [Comparative study of the radiation-protective effectiveness of low doses of cysteamine, heparin, and naphtizine in experiments on mice]. Radiatsionnaia biologiia, radioecologiia / Rossiiskaia akademiia nauk, 41(3), 310-312. [22] Bloxham, S., Eicherà ¢Ã¢â€š ¬Ã‚ Lorka, O., JakubÄ-nas, R., Niaura, G. (2003). Adsorption of Cysteamine at Copper Electrodes as Studied by Surfaceà ¢Ã¢â€š ¬Ã‚ Enhanced Raman Spectroscopy. Spectroscopy letters, 36(3), 211-226. [23] Dayalu, P., Albin, R. L. (2015). Huntington Disease: Pathogenesis and Treatment. Neurologic clinics, 33(1), 101-114. [24] Kurlan, R., Evans, R., Wrigley, S., McPartland, S., Bustami, R., Cotter, A. (2015). Tai Chi in Parkinson’s disease: A Preliminary Randomized, Controlled, and Rater-Blinded Study. Advances in Parkinsons disease, 4(01), 9. [25] Than, N. N., Newsome, P. N. (2015). A concise review of non-alcoholic fatty liver disease. Atherosclerosis. 239(1), 192–202. [26] Bordon, Y. (2015). Microbiota: Gut bacteria cross malaria. Nature Reviews Immunology, 15(1), 1-1. [27] Brawer, J.R. et al. (1994) the origin and composition of peroxidase-positive granules in cysteamine-treated astrocytes in culture. Brain Res. 633, 9–20. [52] Wu, T. M., Lin, Y. W. (2006). Doped polyaniline/multi-walled carbon nanotube composites: Preparation, characterization and properties. Polymer, 47(10), 3576-3582. [53] Xu, J., Yao, P., Li, X., He, F. (2008). Synthesis and characterization of water-soluble and conducting sulfonated polyaniline/ para-phenylenediamine-functionalized multi-walled carbon nanotubes nano-composite. Materials Science and Engineering: B, 151(3), 210-219. [55] Ansari, R., Ajori, S., Rouhi, S. (2015). Elastic properties and buckling behavior of single-walled carbon nanotubes functionalized with diethyltoluenediamines using molecular dynamics simulations. Superlattices and Microstructures, 77, 54-63. [56] Bie, B. X., Han, J. H., Lu, L., Zhou, X. M., Qi, M. L., Zhang, Z., Luo, S. N. (2015). Dynamic fracture of carbon nanotube/epoxy composites under high strain-rate loading. Composites Part A: Applied Science and Manufacturing, 68, 282-288. [57] Shi, Q., Yang, D., Su, Y., Li, J., Jiang, Z., Jiang, Y., Yuan, W. (2007). Covalent functionalization of multi-walled carbon nanotubes by lipase. Journal of Nanoparticle Research, 9(6), 1205-1210. [1] Raw Carbon nanotubes( pure carbon nanotubes: p-MWCNT)

Joan Didions Essay Los Angeles Notebook -- Didion Los Angeles Noteboo

Joan Didion's Essay "Los Angeles Notebook"   Ã‚  Ã‚  Ã‚  Ã‚  The Santa Ana winds cause people to act more violently or unruly and makes others irritable and unhappy to a great extent. Joan Didion explains to the reader about how the Santa Ana affects human behavior in her essay â€Å"Los Angeles Notebook.† Through the use of imagery, diction, and selection of detail Didion expresses her view of the Santa Ana winds.   Ã‚  Ã‚  Ã‚  Ã‚  Didion paints uneasy and somber images when describing the Santa Ana winds. â€Å"There is something uneasy in the Los Angeles air†¦ some unnatural stillness, some tension,† starts the essay off with the image of Los Angeles people in a sense of stillness or tense. She further adds, â€Å"Blowing up sandstorms out along Route 66†¦ we will see smoke back in the canyons, and hear sirens in the night,† propagating the uneasy and stark image of Los Angeles. â€Å"The baby frets. The maid sulks,† she adds, giving a depressing view into the effects of the Santa Ana winds on people. Didion, in an attempt to show the craziness associated with the Santa Ana winds, points out the Indians who throw themselves into the sea when bad winds came. At any rate, Didion attempts to show the negative effects of the Santa Ana winds through images of stillness, uneasiness, and sobriety.   Ã‚  Ã‚  Ã‚  Ã‚  In her tone, Didion remains clear, consistent, and vivid. Her choice of words remains simple as if to not alienate the readers of her essay. Her tone for the first half of the opening, primarily the first and second ...

Psychology Dementia Paper

Alzheimer’s In The Early Years Early-onset Alzheimer's is an uncommon form of dementia that strikes people younger than age 65. In that case, some of the first episodes of symptoms with the early onset start as behavioral problems. The caregiver’s of the early onset patient’s experience a lot of stress in their job of taking care of patients with dementia no matter the gender. The biggest portions of people that suffer from early onset dementia tend to have shown up in family members that are very close to them.Alzheimer’s cannot be reversed so in that case once you have been diagnosed with it, there’s no possible way to change it and all cases end in mortality. There are two types of early onset dementia. There is pre-senile dementia also classified as Alzheimer’s disease because this often happens in patients that are younger than 65 years old. This is cause by the degeneration of the front temporal lobe, progressive supranuclear palsy, and corticobasal degeneration.The patients that tend to be older than 65 that develop dementia share the same characteristics but often nowhere near as sever but could also still be diagnosed as Alzheimer’s depending on the patient’s conditions. Cerebrovascular disorders are age-related processes. In that case VaD, or vascular cognitive diminishing, usually arises in patients older than 65 years of age, but less frequently in patients younger than 65.The early clinical features of front temporal lobar degeneration are changes in personality and social behavior rather than impaired cognition. With progression of the disease, impairment of cognitive functions, including memory, becomes obvious and slowly increases in severity. Stereotypical speech, with prominent reduction of vocabulary, occurs in the advanced stage of illness. Sematic dementia and progressive non-fluent aphasia are characteristic clinical symptoms of front temporal dementia.Rapid progression of cognitive i mpairment with neuropsychological syndromes and neurological symptoms, like spastic pyramidal signs, myoclonia, and convulsions, has been considered characteristics of early onset Alzheimer’s. However, it was reported recently that the spastic paraparesis, seizures, and myoclonic convulsions do not always occur in early onset Alzheimer’s, although language problems and visuospatial dysfunction are common.